Publications

Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry.

American Journal of Geriatric Psychiatry, 2024

Phase 1 study of latozinemab in progranulin-associated frontotemporal dementia

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024

AAV- GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/- Grn-/- mice

iScience, 2023

Targeting Progranulin as an Immuno-Neurology Therapeutic Approach

International Journal of Molecular Sciences, 2023

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

Journal of Translational Medicine, 2023

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology

Stem Cell Reports, 2023

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Nature Medicine, 2022

Progranulin as a therapeutic target in neurodegenerative diseases

Trends in Pharmacological Sciences, 2022

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Cell Reports, 2021

Reduced plasma progranulin levels are associated with the severity of Parkinson's disease

Neuroscience Letters, 2020

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Molecular Neurodegeneration, 2018

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS

PLoS ONE, 2017

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Journal of Neurochemistry, 2017

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access

Journal of Neurochemistry, 2017

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

Molecular Neurodegeneration, 2016

Association Between Progranulin and Gaucher Disease

EBioMedicine, 2016

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Journal of Cell Biology, 2015

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis

Journal of Neurology, 2015

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

Molecular Neurodegeneration, 2014

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Nature Medicine, 2014

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease

Gene, 2014

Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease

PLoS ONE, 2014

Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

Neuroscience, 2013

Progranulin regulates neuronal outgrowth independent of Sortilin

Molecular Neurodegeneration, 2012

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin

Neuron, 2010

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

PLoS ONE, 2010

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

The Journal of Experimental Medicine, 2010

A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology

Brain, 2007

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Nature, 2006