Publications

Shifting paradigms: The central role of microglia in Alzheimer's disease

Neurobiology of Disease, 2019

Microglia in Neurodegeneration

Nature Neuroscience, 2018

Phase 1 study of latozinemab in progranulin-associated frontotemporal dementia

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024

Targeting Progranulin as an Immuno-Neurology Therapeutic Approach

International Journal of Molecular Sciences, 2023

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

Journal of Translational Medicine, 2023

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology

Stem Cell Reports, 2023

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Nature Medicine, 2022

Progranulin as a therapeutic target in neurodegenerative diseases

Trends in Pharmacological Sciences, 2022

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Cell Reports, 2021

Reduced plasma progranulin levels are associated with the severity of Parkinson's disease

Neuroscience Letters, 2020

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Molecular Neurodegeneration, 2018

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS

PLoS ONE, 2017

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Journal of Neurochemistry, 2017

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access

Journal of Neurochemistry, 2017

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

Molecular Neurodegeneration, 2016

Association Between Progranulin and Gaucher Disease

EBioMedicine, 2016

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Journal of Cell Biology, 2015

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis

Journal of Neurology, 2015

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

Molecular Neurodegeneration, 2014

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Nature Medicine, 2014

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease

Gene, 2014

Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease

PLoS ONE, 2014

Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

Neuroscience, 2013

Progranulin regulates neuronal outgrowth independent of Sortilin

Molecular Neurodegeneration, 2012

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin

Neuron, 2010

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

PLoS ONE, 2010

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

The Journal of Experimental Medicine, 2010

A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology

Brain, 2007

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Nature, 2006

Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease

Alzheimer's Research & Therapy, 2024

A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease

Science Translational Medicine, 2022

TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

Cell, 2022

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Nature Neuroscience, 2022

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

Journal of Experimental Medicine, 2022

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Neuron, 2022

Targeting TREM2 for Parkinson’s Disease: Where to Go?

Frontiers in Immunology, 2021

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Acta Neuropathologica, 2020

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Acta Neuropathologica, 2020

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

The Journal of Experimental Medicine, 2020

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Cell, 2020

TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models

The FASEB Journal, 2019

TREM2 function impedes tau seeding in neuritic plaques

Nature Neuroscience, 2019

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

Journal of Biological Chemistry, 2018

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Cell, 2017

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Cell, 2017

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity, 2017

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

European Molecular Biology Organization, 2017

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

Neurobiology of Aging, 2016

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Neuron, 2016

TREM2 regulates microglial cell activation in response to demyelination in vivo

Acta Neuropathologica, 2015

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

Cell, 2015

The TREM2 variant p.R47H is a risk factor for sporadic amyotrophic lateral sclerosis

JAMA Neurology, 2014

TREM2 and neurodegenerative disease

New England Journal of Medicine, 2013

TREM2 variants in Alzheimer's disease

New England Journal of Medicine, 2013